The Family Reported Outcome Measure (FROM-16) is a questionnaire that measures the impact on the quality of life of an adult family member or partner resulting from having a person (of any age) in a family with any disease or condition across all of medicine. It is self-explanatory and can be simply handed to the patient’s family member/partner, who is asked to fill it in without the need for a detailed explanation. FROM-16 has 16 simple questions based on extensive interviews with 140 family members across 26 different medical specialities. It can be used across all fields of medicine. FROM-16 has validated score meaning bands, responsiveness, and defined Minimal Important Change. It is mapped to EQ-5D to calculate utility values and is available in >30 translations.